|
KMID : 1134820230520101035
|
|
Journal of the Korean Society of Food Science and Nutrition
2023 Volume.52 No. 10 p.1035 ~ p.1041
|
|
|
The Effect of Quercetin Analogs on Osteoblast Differentiation
|
|
Kim Kyeong-Min
Jang Jong-Yun
Lim Young-Ju
Kang Dong-Wook
Kim Young-Jong
|
|
|
Abstract
|
|
|
|
In this study, we investigated the effects of quercetin and quercetin analogs on osteoblast differentiation. Analogs (Q-176, -183, -192) obtained by synthesizing gallic acid and quercetin were not toxic to MC3T3-E1 cells as determined by MTT assay but increased the mRNA and protein expressions of Dlx5 and Runx2 (osteoblast differentiation marker genes) ALP and ARS staining showed that quercetin analogs increased ALP enzyme activity and extracellular matrix mineralization. In addition, quercetin analogs increased osteoblast differentiation by increasing caudal fin regeneration in zebrafish. In this study, quercetin analogs more effectively promoted osteoblast differentiation than quercetin, which suggests they have potential use for preventing and treating bone-related diseases.
|
|
|
KEYWORD
|
|
|
quercetin, quercetin analog, osteoblast differentiation, preosteoblast, zebrafish
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|